Translational Research of Ghrelin in Cardiometabolic Diseases and Its Potent Regulatory Role of Autonomic Nerve Function

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390204
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: KISHIMOTO Ichiro 独立行政法人国立循環器病研究センター, 病院, 医長 (80312221)
• Co-Investigator(Kenkyū-buntansha): TOKUDOME Takeshi 国立循環器病研究センター, 研究所, 室長 (00443474) ; KANGAWA Kenji 国立循環器病研究センター, 研究所, 研究所長 (00112417) ; AKAMIZU Takashi 和歌山県立医科大学, 医学部, 教授 (20231813) ; SOEKI Takeshi 徳島大学, ヘルスバイオサイエンス研究部, 講師 (60393211)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: グレリン

Outline of Final Research Achievements

One bolus subcutaneous administration of ghrelin prevents arrhythmia and reduces mortality in the acute phase of myocardial infarction (MI), while continuous administration improves LV dysfunction and attenuates early cardiac remodeling after acute MI. The mechanism of ghrelin’s action is related to down-regulation of the cardiac sympathetic nerve activity (SNA).The detrimental effect of a lack of endogenous ghrelin on malignant arrhythmia within 30 minutes after MI were also demonstrated in mice deficient for ghrelin, which have deteriorated heart function and high mortality after MI. The underlying mechanism is associated with the impaired inhibition of cardiac sympathetic activation by ghrelin.These results suggest existance of the stomach-brain-heart axis.

Free Research Field

循環器代謝学