Development of a new therapy against allergic asthma

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390205
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: University of Tsukuba
• Principal Investigator: TAHARA Satoko 筑波大学, 医学医療系, 講師 (20360589)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 喘息 / アラジン－１ / 肥満細胞 / 樹状細胞

Outline of Final Research Achievements

Allergin-1 is an immunotyrosine-based inhibitory motif (ITIM)-bearing immunoglobulin-like receptor and inhibit FcεRI-mediated activating signal in mast cell (MC). We found that Allergin-1 suppress house dust mite (HDM)-induced serum IgE elevation, lung eosinophilia, and methacholin-induced airway hyperresponsiveness (AHR) in vivo. We also found that treatment of mice with Allergin-1-ligand inhibited IgE-dependent passive cutaneous anaphylaxis in vivo. These results indicate that Allergin-1 may be a promising target molecule for therapy against allergic asthma.

Free Research Field

免疫学