2014 Fiscal Year Final Research Report
Study to overcome metastasis and targeted drug-resistance of lung cancer
Project/Area Number |
24390209
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
|
Research Institution | Kanazawa University |
Principal Investigator |
YANO Seiji 金沢大学, がん進展制御研究所, 教授 (30294672)
|
Co-Investigator(Kenkyū-buntansha) |
EBI Hiromichi 金沢大学, がん進展制御研究所, 助教 (00645145)
OHTSUBO Koshiro 金沢大学, 大学病院, 講師 (60361987)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | 分子標的薬耐性 / 脳転移 / 骨転移 / がん性胸膜炎 |
Outline of Final Research Achievements |
To elucidate mechanism of targeted drug resistance in metastatic lesions, we established in vivo imaging models for pleural carcinomatosis and bone/brain metastases, which are resistant to targeted drugs, of EGFR mutant or ALK fusion positive lung cancer cell lines. We found that resistant tumors consist of a heterogeneous mixture of functionally distinct cancer cells with different resistant mechanisms. Moreover, our observation indicated that we should be careful for toxicity of combined therapy which overcome targeted drug resistance caused by multiple mechanisms.
|
Free Research Field |
腫瘍内科
|