TET2 gene abnormality and epigenetic dysregulation in hematologic malignancies

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390241
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: University of Tsukuba
• Principal Investigator: CHIBA Shigeru 筑波大学, 医学医療系, 教授 (60212049)
• Co-Investigator(Renkei-kenkyūsha): OGAWA Seishi 京都大学, 医学研究科, 教授 (60292900)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: TET2 / T細胞リンパ腫 / エピゲノム

Outline of Final Research Achievements

Mutations in the TET2 gene, which encodes an enzyme converting methylcytosine to hydroxymethylcytosine in the genome, are frequently found in a wide variety of hematologic　malignancies. In this research, we demonstrated frequent novel RHOA gene mutations and the relationship between the mutations of TET2 and RHOA in angioimmunoblastic T-cell lymphoma. These findings were published in Nature Genetics in 2014. Furthermore, using model mice in which TET2 is knocked down, we demonstrated development of T-cell lymphoma and epigenetic dysregulation by the defect of TET2 function.

Free Research Field

血液内科学