2014 Fiscal Year Final Research Report
The role of patrolling monocytes in inflammary dermatoses in which herpesviruses can trigger
Project/Area Number |
24390276
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
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Research Institution | Kyorin University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
MIZUKAAW Yoshiko 杏林大学, 医学部, 准教授 (50301479)
TAKAHASHI Ryo 杏林大学, 医学部, 講師 (00317091)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | ヘルペスウイルス / 単球 / ホーミング / 薬疹 |
Outline of Final Research Achievements |
Many autoimmune diseases are characterized by loss of regulatory T cell (Treg) numbers or their function. Drug-induced hypersensitivity syndrome (DiHS), a distinct phenotype of severe drug eruptions, offers a unique opportunity to link impaired Treg function with subsequent development of autoimmune disease. Our longitudinal study demonstrates that selective depletion of CD14dimCD16+ patrolling monocytes (pMOs) sensing herpesviruses occurring at the acute stage is associated with Treg expansion. After clinical resolution, however, 'pathogenic' pMOs with potent ability to produce IL-6 are alternatively recruited and contribute to the eventual shift away from a Treg to a Th17 responses that is observed at the resolution stage. pMOs would be the major therapeutic target for inflammatory diseases characterized by the shift from a Treg to a Th17 development.
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Free Research Field |
医歯薬学
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