2014 Fiscal Year Final Research Report
Comprehensive analysis of the effect of antipsychotics on DNA methylation in brain
| Project/Area Number |
24390279
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IWAMOTO Kazuya 東京大学, 医学部附属病院, 特任准教授 (40342753)
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| Co-Investigator(Renkei-kenkyūsha) |
BUNDO Miki 東京大学, 医学部附属病院, 特任助教 (00597221)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | エピジェネティクス |
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| Outline of Final Research Achievements |
Epigenetic status such as DNA methylation and histone protein modification is believed to be involved in the pathophyshiology of neuropsychiatric disorders. However, impact of various treatment drugs on epigenetic status remain unclear. In this project, I systematically examined the effect of antipsychotics on DNA methylation using neuroblastoma cell line.
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| Free Research Field |
分子精神医学
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