Comparison of the cerebral function before and after the oxytocin administration for patients with autism spectrum disorder.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390282
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kanazawa University
• Principal Investigator: MINABE Yoshio 金沢大学, 医学系, 教授 (60181947)
• Co-Investigator(Kenkyū-buntansha): MUNESUE Toshio 金沢大学, 子どものこころの発達研究センター, 特任教授 (50293353) ; KIKUCHI Mitsuru 金沢大学, 子どものこころの発達研究センター, 特任教授 (00377384) ; OUCHI Yasuomi 浜松医科大学, 分子イメージング先端研究センター, 教授 (40436978)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: オキシトシン / 自閉症スペクトラム / セロトニン / PET

Outline of Final Research Achievements

With chronic administration of the oxytocin to the patients with autism spectrum disorder who does not have intelligence impairment, we investigated the influence on the serotonin system and the influence on a social cognitive function. The neurophysiological characterization of the patient who improves with oxytocin administration was also explored. We investigated the changes of the serotonin transporter density after the drug treatment (ten weeks), and we also investigated the changes in brain response to social stimuli recorded by MEG. Study desing: Non-randomized, open and uncontrolled.

Free Research Field

精神医学全般