2015 Fiscal Year Final Research Report
A systematic approach to achieve glioblastoma cure via targeting glioma stem cells
| Project/Area Number |
24390338
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NEMOTO KENJI 山形大学, 医学部, 教授 (10208291)
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| Co-Investigator(Renkei-kenkyūsha) |
SATO ATSUSHI 山形大学, 医学部, 助教 (30455901)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | glioma-initiating cell |
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| Outline of Final Research Achievements |
In this project, we searched for drugs that are capable of differentiating glioblastoma stem cells into non-stem glioblastoma cells. Here we discovered that an anti-diabetic drug metformin induces the differentiation of glioblastoma stem cells into non-stem glioblastoma cells through the activation of FoxO3a. Furthermore, we discovered that JNK, a serine/threonine kinase implicated in cellular signaling, plays an essential role in the maintenance of glioblastoma stem cells and also demonstrated that a JNK inhibitor has a differentiation-inducing activity against glioblastoma stem cells.
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| Free Research Field |
脳神経外科学、脳腫瘍学
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