Molecular mechanisms underlying the rupture of cerebral aneurysms and the pharmacological regulation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390344
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: The University of Tokushima
• Principal Investigator: NAGAHIRO Shinji 徳島大学, ヘルスバイオサイエンス研究部, 教授 (60145315)
• Co-Investigator(Kenkyū-buntansha): SATOMI Junichiro 徳島大学, 大学院ヘルスバイオサイエンス研究部, 准教授 (10304510) ; TADA Yoshiteru 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (30547964) ; KUWAYAMA Kauyuki 徳島大学, 病院, 講師 (50614236) ; MORIGAKI Ryoma 徳島大学, 大学院ヘルスバイオサイエンス研究部, 特任助教 (70710565)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脳・神経 / 脳血管病 / エストロゲン / 脳動脈瘤破裂 / 血行動態変化 / 高血圧

Outline of Final Research Achievements

Subarachnoid hemorrhage is a catastrophic event and directs to high mobility and bad prognosis. To prevent this event, it is required to verify the pathogenesis. Hemodynamic stress is one of the initiating factors for cerebral aneurysmal formation. We hypothesized that additive hemodynamic change accelerates the development of aneurysms and studied the hypothesis. Ten-weeks-old Sprague-Dawley female rats were additively occluded in Rt.PPA and Rt.ECA. Their rupture incidence and the rupture rate were increased. The development of aneurysms at the circle of Willis may be partly attributable to hemodynamic change. Using this model we will study the efficacy of pharmacological treatment such as telmisartan, eplerenone or cilostazol. On the other hand, we started the clinical studies to assess the pharmacological treatment of cerebral aneurysms.

Free Research Field

脳神経外科学