Development of TNF-receptor Antagonists which have both Anti-inflammatory Action and Bone Formation Activity and Apply Them for the Treatment of Periodontal Diseases.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390413
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: OHYA Keiichi 東京医科歯科大学, 歯学部, 非常勤講師 (10126211)
• Co-Investigator(Kenkyū-buntansha): AOKI Kazuhiro 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (40272603) ; TAKAHASHI Mariko 東京医科歯科大学, 歯学部, 技術職員 (90334440)
• Co-Investigator(Renkei-kenkyūsha): NIFUJI Akira 鶴見大学, 歯学部, 教授 (00240747)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: TNF拮抗薬 / 硬組織 / 破骨細胞 / 骨芽細胞 / 骨形成 / 骨吸収 / 歯周病 / 炎症性疾患

Outline of Final Research Achievements

Inflammation caused by periodontal disease, which is a typical disease of the dental region, induces jaw bone resorption. Jaw bone resorption finally promotes the loss of teeth, leading to a decline of masticatory function. So to aim the development of drug therapies that can treat and prevent periodontal disease, we examined the cyclic peptide W9, which inhibits the binding of TNF and TNF receptor. W9 peptide showed a bone resorption inhibitory action through the mechanism that inhibits the interaction of RANK / RANKL, which is important for a growth and differentiation process of osteoclasts. In addition, W9 peptide was found to possess a bone formation promoting action as shown by the detailed study of the effect of the W9 peptides on bone. Further, by exploring the DDS system of W9 peptide, the peptide was shown to be useful for the treatment of the inflammatory bone resorption disease such as the periodontal disease.

Free Research Field

歯科薬理学