Pathogenesis of T cell-mediated immune disorders in oral mucosa

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390422
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Fukuoka Dental College
• Principal Investigator: OHNO Jun 福岡歯科大学, 歯学部, 講師 (10152208)
• Co-Investigator(Kenkyū-buntansha): OKAMURA Kazuhiko 福岡歯科大学, 口腔歯学部, 准教授 (00224056) ; KAWAGUCHI Minoru 福岡歯科大学, 口腔歯学部, 講師 (10122780) ; FUKUSHIMA Tadao 福岡歯科大学, 口腔歯学部, 教授 (80084250)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 口腔粘膜疾患 / T細胞 / 上皮親和性 / マクロファージ / 自己免疫応答 / エフェクター細胞

Outline of Final Research Achievements

In oral mucosal lesions developed by mercury-induced autoimmune response, MHC classII- and ED1-positive macrophages infiltrated into the basement membrane (BM) zone of surface epithelium. A lupus-band was observed in the oral epithelial BM in addition to renal glomeruli. Local autoimmune responses may be involved in the pathogenesis of lupus-like lesions of the oral mucosa. In the satellitosis-typed oral mucosal lesions developed by systemic graft-versus-reaction, binding of mannose (Man)-specific LCA lectin expanded to the epithelial layers. An expansion of LCA binding was related to the increased expression of mannosyltransferase in the oral mucosa. Effector cells of the satellitosis-typed lesions expressed Man-binding protein (BMP) and migrated to the medium containing Man. These results suggest that the migration and/or adhesion of effector cells in the epithelium may be mediated in part by the MBP/Man-binding pathway during the development of satellitosis-typed lesions.

Free Research Field

口腔病理学