Establishment of the medical support to inpatients by oral health management applied with Kampo medicine

2015 Fiscal Year Final Research Report

• Project/Area Number: 24390471
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: HINODE Daisuke 徳島大学, 大学院医歯薬学研究部, 教授 (70189801)
• Co-Investigator(Kenkyū-buntansha): IGA Hiroki 徳島大学, 大学院医歯薬学研究部, 教授 (40175188) ; YOSHIOKA Masami 徳島大学, 大学院医歯薬学研究部, 准教授 (90243708) ; KAWAZOE Kazuyoshi 徳島大学, 大学院医歯薬学研究部, 教授 (00248296) ; YOSHIDA Kaya 徳島大学, 大学院医歯薬学研究部, 講師 (60363157) ; DOI Tokiko 徳島大学, 大学院医歯薬学研究部, 助教 (70747683)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 漢方薬 / 歯周病原細菌 / 専門的口腔ケア / 抗がん剤 / 口腔粘膜炎 / 食道がん / 口腔保健管理 / 大黄甘草湯

Outline of Final Research Achievements

The results of basic research indicated that the increase of reactive oxygen species production was consider to be associated with the cell death induced by 5-FU and TJ-84 may attenuate 5-FU-induced cell death. The results of clinical research showed that the onset of severe oral mucositis was reduced by intervention of professional oral health care for esophagus cancer patients during chemotherapy. TJ-84 acted as a drug effect on periodontopathogenic bacteria, F. nucleatum and C. rectus and significantly decreased a number of these bacteria in addition to reduced gingival inflammation. These findings suggest that it may be useful for cancer patients in supportive cure by oral health management applied with Kampo medicine.

Free Research Field

予防歯科学