Spatial and temporal analyses on the historical dispersals and natural selection in the house mouse Mus musculus

2015 Fiscal Year Final Research Report

• Project/Area Number: 24405013
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Biodiversity/Systematics
• Research Institution: Hokkaido University
• Principal Investigator: Suzuki Hitoshi 北海道大学, 地球環境科学研究科(研究院), 教授 (40179239)
• Co-Investigator(Kenkyū-buntansha): SATO Jun 福山大学, 生命工学部, 准教授 (80399162)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: ハツカネズミ / ヒト随伴動物 / 選択的スイープ / 自然選択 / 毛色関連遺伝子 / ハプロタイプ構造解析 / アジア農耕史 / 二次的接触

Outline of Final Research Achievements

We examined genetic variation in house mice and provide insight into the ancient divergence of the three subspecies groups, castaneus (CAS), domesticus (DOM), and musculus (MUS) in Middle East and India. We examined seven tandemly arranged nuclear genes on chromosome 8. STRUCTURE analysis suggested subdivision of CAS into two main haplogroups within the Indian subcontinent. Single-gene networks revealed gene-specific architecture for subgrouping in CAS and allelic exchange among subspecies, suggesting that the earlier onset of allopatric divergence in the predicted homeland and subsequent intermittent admixing via gene flow within and between subspecies groups. A comparison of the levels of nucleotide diversity among the gene regions revealed a less divergent state in the chromosome region containing Mc1r and its adjacent genes, indicative of a selective sweep, suggesting the involvement of natural selection in the Mc1r allelic variation.

Free Research Field

系統地理学