Genome-wide DNA analysis on people with family name "Japan" in Spain who are presumed as descendants of a part of the delegation to Rope by Masamune Date

2016 Fiscal Year Final Research Report

• Project/Area Number: 24405017
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Physical anthropology
• Research Institution: Nagoya University
• Principal Investigator: Yamamoto Toshimichi 名古屋大学, 医学(系)研究科(研究院), 准教授 (50260592)
• Co-Investigator(Kenkyū-buntansha): 斎藤 成也 国立遺伝学研究所, 集団遺伝学系, 教授 (30192587)
• Co-Investigator(Renkei-kenkyūsha): TOKUNAGA Katsushi 東京大学, 大学院医学系研究科, 教授 (40163977)
• Research Collaborator: FUSE Nobuo ; NAGASAKI Masao ; KAWAI Yosuke ; FUSE Nobuo ; CARRACEDO Angel
• Project Period (FY): 2012-04-01 – 2017-03-31
• Keywords: ハポン姓 / 日本人 / スペイン / ゲノムワイド / SNP解析 / Yハプロタイプ

Outline of Final Research Achievements

Among 800 people with family name indicated “Japan” in Spanish lived in Coria del Rio near Seville in Spain, 50 males and 51 females wishfully donated their blood with written informed consents to perform DNA analyses to confirm tips of Japanese traces on their genomes scientifically. DNA samples were extracted in by collaborators Spain, and all of the DNA analyses were performed in Japan. Unfortunately, the results of Y-STR (STRs on Y chromosome) haplotype analysis for male samples, all of the haplotypes were not similar to Japanese ones, but close to Spanish or other countries' ones. Genome-wide SNP analysis with the Japonica Array where almost all of about 660K SNPs were specific to Japanese genome also could not revealed any Japanese traces on their genomes by comparing with those data from 8 indigenous Japanese and in Tohoku Medical Mega Bank, and from Spain DNA Bank. In future, other newly improved and developed techniques or analyses would be successful to certify this matter.

Free Research Field

法医学