Virus-host coevolution and new virus prediction

2015 Fiscal Year Final Research Report

• Project/Area Number: 24405045
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Applied veterinary science
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: ARAI SATORU 国立感染症研究所, その他部局等, 研究員 (80321868)
• Co-Investigator(Kenkyū-buntansha): OHDACHI SATOSHI 北海道大学, 低温科学研究所, 助教 (60292041) ; SUZUKI HITOSHI 北海道大学, 地球環境科学研究科, 教授 (40179239) ; KAWADA SHINICHIRO 国立科学博物館, 動物研究部, 研究員 (30415608) ; FUKUI DAI 東京大学, 農学生命科学研究科, 助教 (60706670)
• Co-Investigator(Renkei-kenkyūsha): MORIKAWA SHIGERU 国立感染症研究所, 獣医科学部, 部長 (00167686)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 共進化 / ウイルス予測 / 新型ウイルス / ハンタウイルス

Outline of Final Research Achievements

During this research, we conducted the filed investigation of small animals in Vietnam and Myanmar for nine times. We captured a total of 1,039 rodents, shrews and bats animals. The infected virus in the animals, novel hantavirus RNAs were successfully detected in two species of insectivore bats, captured in Vietnam in 2012 and 2015. We conducted phylogenetic analysis based on the sequence data of newly-discovered viruses and deposited ones in GenBank. It showed that chiroptera-borne hantaviruses consisted of one cluster and also co-evolved with host mammalian animals. Detailed phylogenetic analyses, based on partial and full-length genomes of previously described rodent-borne and newly detected non-rodent-borne hantaviruses indicate an Eurasian origin and support the emerging concept that ancestral non-rodent mammals may have served as the hosts of primordial hantaviruses. The results of phylogenetic analysis would be able to be used for virus prediction in near future.

Free Research Field

感染症