2014 Fiscal Year Final Research Report
Emotional arousal in deacetylase-deficient mice and its underlining mechanism
Project/Area Number |
24500453
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Institute for Developmental Research, Aichi Human Service Center |
Principal Investigator |
KAWAGUCHI yoshiharu 愛知県心身障害者コロニー発達障害研究所, 発生障害学部, 主任研究員 (00450833)
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Research Collaborator |
TAKESHIMA Kyoko 愛知県心身障害者コロニー発達障害研究所, 発生障害学部, 実験補助
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | HDAC6 / セロトニン / 抗うつ / 脱アセチル化 / ピルビン酸 |
Outline of Final Research Achievements |
Our major goal is to provide a new aspect of understanding psychiatric diseases. To address this issue, we focus HDAC6 knockout mice that show hyperactivity, less anxiety, and antidepressant-like behavior. In this study, we found the disturbance of neuronal activity in both serotonergic and dopaminergic neurons in HDAC6 KO mouse brain by evaluating the amount of monoamines, tryptophan hydroxylase, and dopamine D2 receptor. We also found that loss of deacetylate activity induces the accumulation of pyruvate accompanied by the reduction in ATP in raphe and PC12 cells, suggesting energy disability in serotonergic neurons in HDAC6 KO mice. Our findings demonstrate that deacetylate activity of HDAC6 might contribute to maintain the proper function in energy metabolism in serotonergic neurons, and its disturbance affects neuronal activity, leading to emotional arousal in mice.
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Free Research Field |
神経科学
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