Elucidation of pathogenesis of autoimmune diseases in animal models by comprehensive metabolomic profiling

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500491
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory animal science
• Research Institution: Kobe University
• Principal Investigator: YOKOI Norihide 神戸大学, 医学(系)研究科(研究院), 特命准教授 (70311610)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 病態発症機構 / 自己免疫疾患 / 疾患モデル / バイオマーカー / 代謝物・代謝経路 / メタボローム / 1型糖尿病 / 自己免疫性甲状腺炎

Outline of Final Research Achievements

In this study, we aimed to elucidate pathogenesis of autoimmune diseases (autoimmune type 1 diabetes and autoimmune thyroiditis) in animal models by comprehensive longitudinal metabolomic profiling. From the viewpoint of metabolome, metabolites and metabolic pathways which are involved in the pathogenesis of autoimmune diseases were identified. Novel biomarker candidates which reflect the state of diseases were also found. These results could lead to the development of novel diagnosis and evaluation methods of autoimmune diseases.

Free Research Field

実験動物学、分子代謝学