Inhibition of GABAregic synapeses modulates motor control and the expression of neurotrophins in motor cortex

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500619
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Hokkaido University (2014); Teikyo University of Science & Technology (2012-2013)
• Principal Investigator: MAEJIMA HIROSHI 北海道大学, 大学院保健科学研究院, 教授 (60314746)
• Co-Investigator(Kenkyū-buntansha): 金村 尚彦 埼玉県立大学, 保健医療福祉学部, 准教授 (20379895)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 運動 / 神経栄養因子 / GABA / シナプス

Outline of Final Research Achievements

The objective of the present study was to investigate the effects of exercise and the inhibition of GABAegic synapses on the expression of neurotrophins in the mouse motor cortex. After the intervention compromising exercise and GABAA receptpr blockage for 10 days, where exercise significantly increased the expression of BDNF and NT-4, GABAA receptor blockade of sedentary mice showed no effect on the expression of the neurotrophins. On the contrary, GABAA receptor blockade of exercised mice significantly decreased the expression of BDNF and NT-4 to the level of sedentary mice, indicating that GABAA receptor blockade removed the exercise-induced up-regulation of BDNF and NT-4. Taken together, the present study elucidated that GABAA receptor blockade negatively modifies exercise-induced up-regulation of neurotrophins and neural activity in the motor cortex.

Free Research Field

理学療法学