Production of oxidized LDL during exercise in persons with spinal cord injury

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500748
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Wakayama Medical University
• Principal Investigator: MITSUI Toshihito 和歌山県立医科大学, みらい医療推進センター, 助教 (70564186)
• Co-Investigator(Kenkyū-buntansha): TAJIMA Fumihiro 和歌山県立医科大学, 医学部, 教授 (00227076) ; NAKAMURA Ken 和歌山県立医科大学, 医学部, 准教授 (80299635) ; ITO Tomoyuki 和歌山県立医科大学, みらい医療推進センター, 講師 (90305566) ; MABUCHI Hiroyuki 和歌山県立医科大学, みらい医療推進センター, 研究員 (50365508)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 障害者スポーツ / 酸化LDL / 脊髄損傷 / 車いすマラソン

Outline of Final Research Achievements

In persons with cervical spinal cord injury (CSCI), adrenalin secretion during exercise is absent due to a loss of sympathetic nervous control for adrenal medulla, while it’s intact in persons with lumbar spinal cord injury (LSCI). We hypothesized that a loss of adrenalin secretion during exercise would be associated with a production of oxidized LDL. Now we observed that both of oxidized LDL and plasma adrenaline did not increase in CSCI, while both increased in LSCI. The present results suggest that no increase in oxidized LDL for CSCI is associated with the loss of adrenalin secretion and that CSCI can exercise safely until at the exercise intensity set up in the present study.

Free Research Field

スポーツ科学