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2014 Fiscal Year Final Research Report

Cistromic analysis of EMT regulators in breast cancer cells

Research Project

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Project/Area Number 24501311
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor biology
Research InstitutionThe University of Tokyo

Principal Investigator

KOINUMA Daizo  東京大学, 医学(系)研究科(研究院), 准教授 (80375071)

Project Period (FY) 2012-04-01 – 2015-03-31
KeywordsFAIRE-seq / シグナル伝達 / EMT / 乳がん / TGF-beta / ZEB1 / アポトーシス / ゲノム
Outline of Final Research Achievements

Transcriptomic analysis was performed by RNA-seq during EMT of mammary epithelial cells. We found a list of differentially expressed non-coding RNAs during this process. We identified lncRNA-Smad7 as an anti-apoptotic non-coding RNA. A FAIRE-seq dataset was also obtained and we observed promising data showing the dynamic changes in the open chromatin regions during EMT.

Free Research Field

分子病理学、腫瘍生物学、ゲノム科学

URL: 

Published: 2016-06-03  

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