2014 Fiscal Year Final Research Report
Cistromic analysis of EMT regulators in breast cancer cells
| Project/Area Number |
24501311
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KOINUMA Daizo 東京大学, 医学(系)研究科(研究院), 准教授 (80375071)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | FAIRE-seq / シグナル伝達 / EMT / 乳がん / TGF-beta / ZEB1 / アポトーシス / ゲノム |
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| Outline of Final Research Achievements |
Transcriptomic analysis was performed by RNA-seq during EMT of mammary epithelial cells. We found a list of differentially expressed non-coding RNAs during this process. We identified lncRNA-Smad7 as an anti-apoptotic non-coding RNA. A FAIRE-seq dataset was also obtained and we observed promising data showing the dynamic changes in the open chromatin regions during EMT.
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| Free Research Field |
分子病理学、腫瘍生物学、ゲノム科学
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