Toll-like receptor-mediated hepatic premetastatic microenvironment

2014 Fiscal Year Final Research Report

• Project/Area Number: 24501321
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: DEGUCHI Atsuko 東京女子医科大学, 医学部, 助教 (10422932)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 大腸がん / 肝転移 / 微小環境

Outline of Final Research Achievements

Primary tumor developed a pre-metastatic niche in distant organs such as liver, lung, or lymph node. In the case of colorectal cancer, liver is one of favorable organs for distant metastasis. To identify molecules that play an important role in development of hepatic premetastatic niche, we performed microarray analysis using RNA obtained from liver at premetastatic phase. Among these up-regulated genes, we have focused on a chemokine-like protein as a candidate for the establishment of premetastatic niche. We suggest that the molecule can function as a TLR ligand, and it plays a crucial role in the establishment of premetastatic niche in liver.

Free Research Field

腫瘍生物学