A novel prevention method for re-obstruction using titanium alloy stent with ultrasonic irradiation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24501355
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Clinical oncology
• Research Institution: Keio University
• Principal Investigator: ITANO Osamu 慶應義塾大学, 医学部, 講師 (90265827)
• Co-Investigator(Kenkyū-buntansha): MATSUDA Sachiko 慶應義塾大学, 医学部, 特任助教 (90534537)
• Co-Investigator(Renkei-kenkyūsha): SHIMIZU Nobuaki 金沢大学, 学内共同施設等, 教授 (50019634) ; OGINO Chiaki 神戸大学, 工学(系)研究科(研究院), 准教授 (00313693) ; FUJIMURA Tomonori 慶應義塾大学, 医学部, 助教 (30594634) ; SAYA Hideyuki 慶應義塾大学, 医学部, 教授 (80264282) ; OOSHIMA Nobuyuki 金沢大学, 医学(系)研究科(研究院), 教授 (40324610)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 金属ステント / フリーラジカル / 超音波

Outline of Final Research Achievements

Palliative biliary drainage using a metallic stent is performed for biliary obstruction by unresectable biliary carcinoma. The biggest issue of biliary stenting therapy is re-obstruction due to tumor ingrowth. The generation of hydroxyl radical was reported during ultrasonic irradiation (US) in the presence of TiO2. The metal stent for biliary drainage is made of titanium alloy, and it could generate hydroxyl radicals with US. The aim of this study was to investigate a novel prevention method for re-obstruction using ultrasonic irradiation.
Higher free radical generation and cytocidal action were observed with titanium alloy with US than US alone. The stent re-obstruction nude mice model which were a stent implanted to the neighborhood of tumor were given 10 minutes US of 1000 KHｚ, 0.3W /㎠ once a day for 14 days. Tumor ingrowth to the stent was seen in the non-irradiation group and it was inhibited in the irradiation group.

Free Research Field

外科学