Antitumor Action of the MET Tyrosine Kinase Inhibitor in Gastric Cancer Positive for MET Amplification

2014 Fiscal Year Final Research Report

• Project/Area Number: 24501360
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Clinical oncology
• Research Institution: National Cancer Center Japan (2013-2014); Kinki University (2012)
• Principal Investigator: OKAMOTO Wataru 独立行政法人国立がん研究センター, 早期・探索臨床研究センター, 医員 (30441075)
• Co-Investigator(Kenkyū-buntansha): NAKAGAWA Kazuhiko 近畿大学, 医学部, 教授 (40298964) ; NISHIO Kazuto 近畿大学, 医学部, 教授 (10208134) ; OKAMOTO Isamu 九州大学, 大学病院, 学術研究員 (10411597) ; ARAO Tokuzo 近畿大学, 医学部, 講師 (20441074)
• Research Collaborator: KAWAKAMI Hisato
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: MET遺伝子増幅 / 胃癌 / 分子標的薬

Outline of Final Research Achievements

We previously showed that induction of apoptosis underlies the antiproliferative effect of MET tyrosine kinase inhibitors (MET-TKIs) in gastric cancer cells with MET amplification. In the present study, we showed the molecular mechanism underlying its MET-TKIs-induced apoptosis. We also determined the prevalence, clinical features and prognosis of gastric cancer with MET amplification. We further established the MET-TKIs-resistant gastric cancer cell lines, which is important to reveal the MET-TKIs-resistant mechanisms.

Free Research Field

消化器癌、トランスレーショナルリサーチ