Application of probability theory to the generation of double-strand breaks of DNA

2014 Fiscal Year Final Research Report

• Project/Area Number: 24540128
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General mathematics (including Probability theory/Statistical mathematics)
• Research Institution: Hiroshima University
• Principal Investigator: SAISHO Yasumasa 広島大学, 工学(系)研究科(研究院), 准教授 (70195973)
• Co-Investigator(Kenkyū-buntansha): KANAGAWA Shuya 東京都市大学, 共通教育部, 教授 (50185899) ; HATAUE Itaru 金沢大学, 理工学域電子情報学系, 教授 (50218476) ; ITO Atsushi 東海大学, 工学部, 教授 (80193473)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 確率モデル / ＤＮＡ / ２本鎖切断 / 放射線量 / 線エネルギー付与

Outline of Final Research Achievements

First, we got the dose dependence of the generation of DNA double-strand breaks (dsbs) by constructing stochastic models and published a paper of this results.
Next, we considered the double dependence of the generation of dsbs on dose and linear energy transfer (LET) by extending our previous mathematical models.
We also found that the theory of hitting times of a Brownian motion is deeply related to this problem.

Free Research Field

数学（確率論）、数理生物学