Fabrication of Gd(III)-DTPA-nanodiamond Particles by Chemical Modification for Magnetic Resonance Imaging (MRI) Contrast Agents

2014 Fiscal Year Final Research Report

• Project/Area Number: 24560037
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thin film/Surface and interfacial physical properties
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: NAKAMURA Takako 独立行政法人産業技術総合研究所, 先進製造プロセス研究部門, 主任研究員 (70357656)
• Co-Investigator(Kenkyū-buntansha): HASEBE Terumitsu 東海大学, 医学部, 教授 (20306799)
• Co-Investigator(Renkei-kenkyūsha): OHANA Tsuguyori 独立行政法人産業技術総合研究所, 先進製造プロセス研究部門, グループ長 (10356660)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ナノダイヤモンド粒子 / 表面化学修飾 / ガドリニウム / 核磁気共鳴画像 / 造影剤

Outline of Final Research Achievements

We have developed a simple and useful process for fabricating nanodiamond (ND) particles modified with an organogadolinium moiety by chemical modification for their use as a magnetic resonance imaging (MRI) contrast agent. The introduction of the organogadolinium moiety on the surface of the ND particles was performed by the condensation of ND and diethylenetriaminepentaacetic acid (DTPA) followed by treatment with GdCl3. The modified surfaces were evaluated by X-ray photoelectron spectroscopy, diffuse reflectance Fourier transform infrared spectroscopy, mass spectroscopy and inductively coupled plasma atomic emission spectroscopy analyses. MRI experiments on the Gd-DTPA-ND particles indicated their high signal intensity on T1-weighted images.

Free Research Field

炭素材料化学