2014 Fiscal Year Final Research Report
Foundamental research for microparticle formation by rapid expansion of supercritical solution method
| Project/Area Number |
24560921
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Properties in chemical engineering process/Transfer operation/Unit operation
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 微粒子 / 超臨界二酸化炭素 / 薬用成分 / 粒度分布 / 結晶 / 形態変化 / 拡散律速モデル / 表面反応律速モデル |
|---|
| Outline of Final Research Achievements |
The purpose of this work is clarify the influence of the concentration of solute in supercritical carbon dioxide on the forms of the generated fine particles of medicinal component via rapid expansion of supercritical solution.
Submicron fine particles and crystalline coarse particles were observed at high concentration region. Only submicron fine particles were observed at lower concentration of solute. The forms of generated particles were observed and the size distribution was determined by the SEM image.
The two particle formation mechanism, surface reaction control and diffusion control models, were considered to represent the formation of submicron fine particles and crystalline coarse particles. The mean particle sizes were well represented by the two models.
|
| Free Research Field |
化工物性，エアロゾル科学
|
