2014 Fiscal Year Final Research Report
Why the energy transduction efficiency of F1-ATPase so high?
| Project/Area Number |
24570187
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Chuo University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 生体エネルギー変換 / 分子モーター / F1-ATPase |
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| Outline of Final Research Achievements |
F1-ATPase is a highly efficient molecular motor. In order to understand the high efficiency, we compared the high efficient wild type motor with a low efficient mutant (beta G158A, T165S, Y341W), which is less sensitive to ADP inhibition and generates less torque. We found that this mutant motor dissipates "heat" in the rotational degree of freedom than wild type. We could achieve a quantitative measurement on the energy transduction by biological molecular motor which must be useful for understanding of energy transduction.
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| Free Research Field |
生物物理学
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