2015 Fiscal Year Final Research Report
Study of cell interacting mechanism during fish tissue regeneration
| Project/Area Number |
24570233
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
Kawakami Atsushi 東京工業大学, 生命理工学研究科, 准教授 (00221896)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Keywords | ゼブラフィッシュ / 再生 / 細胞系譜 / トランスジェニック / Fgfシグナル |
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| Outline of Final Research Achievements |
To understand the molecular processes of tissue regeneration, we aimed to elucidate the signalling mechanism and cellular functions that control the zebrafish fin regeneration. We analyzed the role of Fgf signals during regeneration and revealed the essential functions of Fgf20a and Fgf3. Further, we analyzed a mutant that displays the apoptosis of regenerating cells and showed that a diffusible substance from the myeloid cells supports the survival and proliferation of regenerating cells.
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| Free Research Field |
生物学
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