2014 Fiscal Year Final Research Report
Analysis of the mechanism of fatty acid synthesis regulation by a novel feeding response gene and its application in anti-obesity therapy
| Project/Area Number |
24580175
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
INOUE Jun 東京大学, 農学生命科学研究科, 准教授 (70323962)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 脂肪酸合成 / 脂肪肝 / LXR / ACC |
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| Outline of Final Research Achievements |
We demonstrated that MIG12, a novel feeding response gene, stimulates the activity of ACC by accelerating ACC polymer formation. We also showed that leucine zipper domains located at the C-terminal of MIG12 contribute to the regulation of ACC. These results indicate that MIG12 is a novel modulator of lipogenesis.
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| Free Research Field |
食品生化学
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