2014 Fiscal Year Final Research Report
Chemoprevention of microcystin poisoning using fisheries waste
| Project/Area Number |
24580304
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | マイクロシスチン / セラミド誘導体 / アメリカオオアカイカ / ナリンジン / フラボノイド / アノイキス抵抗性 |
|---|
| Outline of Final Research Achievements |
The chemical compounds were screened capable of suppressing the cytotoxicity of liver-selective toxin microcystin-LR derived from blue-green algae. This screening was aimed to be the foundation for the establishment of chemical prevention or remedy of liver cancer and liver dysfunction. Ceramide aminoethylphosphonate isolate from skin of the Jumbo flying squid waste potently attenuated the cytotoxicity of microcystin-LR. Furthermore, naringin which is a kind of flavonoid isolated from citrus was also attenuated the cytotoxicity.
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| Free Research Field |
水圏生命科学
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