2014 Fiscal Year Final Research Report
Iodocyclization of ynamides
| Project/Area Number |
24590038
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | イナミド / 環化反応 / ヨウ素 / 複素環 |
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| Outline of Final Research Achievements |
Ynamides are useful synthons because they exhibit high reactivity toward electrophiles and can be adapted to asymmetric reactions if ynamides are chiral. Therefore, I have developed the iodocyclization of ynamides: for examples, benzofuran synthesis was achieved within three seconds in milder reaction conditions than using normal alkynes. In addition, 6-endo type iodocyclization of homopropargylic hydrazides as substrates proceeded by using ynamides to afford dihydropyridazines. Furthermore, tandem dearomative iodocyclization/ Diels-Alder reaction and polyene cyclization using chiral ynamides were demonstrated in diastereoselective manner to obtain optically active spiro rings and tricyclic skeletons.
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| Free Research Field |
有機化学
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