Dvelopment of novel anti-obesity agents targeting cell-surface F1F0-ATP synthase

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590081
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: The University of Tokushima
• Principal Investigator: ARAKAKI Naokatu 徳島大学, ヘルスバイオサイエンス研究部, 准教授 (60151148)
• Co-Investigator(Kenkyū-buntansha): YAMAZAKI Tetsuo 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (90330208) ; NEMOTO Hisao 徳島大学, 大学院ヘルスバイオサイエンス研究部, 准教授 (30208293)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: Ｆ１Ｆｏ-ＡＴＰ合成酵素 / 脂肪細胞 / 細胞内中性脂肪 / 抗肥満薬

Outline of Final Research Achievements

Cell-surface F1F0-ATP synthase plays a role on intracellular triacylglycerol (TG) accumulation in adipocytes. Here we show that cell-surface F1F0-ATP synthase on adipocytes is functional in extracellular ATP production and that the extracellular ATP produced contributes, at least in part, to the cell-surface F1F0-ATP synthase-mediated intracellular triacylglycerol (TG) accumulation in adipocytes through P2Y1 receptor. We synthesized water-soluble resveratrol and piceatannol which are F1F0-ATP synthase inhibitors) and found that these compounds significantly lowered abdominal visceral adipose tissue in diet-induced obese mice.

Free Research Field

医歯薬学