2014 Fiscal Year Final Research Report
Research for the novel metabolic routes of endogenous marijuana-like substance, lysophosphatidylinosiol.
| Project/Area Number |
24590095
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SASAKI Yoko (NEMOTO Yoko) 帝京大学, 薬学部, 講師 (90324110)
HAYASHI Yasuhiro 帝京大学, 薬学部, 助教 (70582857)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | リゾリン脂質 / ホスホリパーゼA / ホスファチジルイノシトール / リゾホスファチジルイノシトール / ホスファチジン酸 / 遺伝性痙性対麻痺 / カンナビノイド / GPR55 |
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| Outline of Final Research Achievements |
The actions of tetrahydrocannabinol are known to be mediated by two G-protein-coupled receptors CB1 and CB2. Recently, another receptor GPR55 has been proposed as a novel type of cannabinoid receptor. We identified lysophosphatidylinositol (LPI) as an agonist for GPR55, and found that the intracellular phospholipase A1 (DDHD1) was involved in the formation of 2-arachidonoyl LPI. We also found that 1-stearoyl LPI was formed by the reverse reaction of lysophosphatidylinositol acyltranferase (LPIAT/MBOAT7).
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| Free Research Field |
医歯薬学
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