2014 Fiscal Year Final Research Report
Regulatory mechanism of diverse G protein signaling in cortical development
| Project/Area Number |
24590113
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Aomori University (2014)
Nara Institute of Science and Technology (2012-2013) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | シグナル伝達 / 神経科学 / 脳・神経 / 薬学 |
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| Outline of Final Research Achievements |
To analyze the regulatory mechanisms of diverse G protein signaling in cortical development, (1) we investigated the function of Ric-8A/B, which are novel non-receptor type G protein regulators, in neural stem cells. We found that Ric-8A/B was related to the neural stem cell proliferation, and more, Ric-8B was involved in the facilitatory effect of Gs signaling on the cell migration. (2) We generated the functional antibodies against human GPR56, which inhibited the glioma cell migration. These antibodies revealed that human GPR56 inhibited the cell migration through Gq/Rho pathways.
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| Free Research Field |
生化学、神経科学、細胞生物学
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