2014 Fiscal Year Final Research Report
Synthesis of Nucleoside Derivatives Applicable to Nucleic Acid Medicine
| Project/Area Number |
24590143
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | Nucleoside / aniti-HIV / antiherpes / Nucleic acid medicine |
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| Outline of Final Research Achievements |
To develop nucleoside derivatives applicable to introduce an oligonucleotide which can be used as nucleic acid medicine, design and synthesis of new nucleosides were investigated. We designed the following three nucleoside derivatives: 1) dihydropyranonucleoside, 2) L-threopentofuranosyl nucleoside, 3) 3’-deoxy-4’-thionucleoside. L-Threopentofuranosyl nucleoside was further converted to the corresponding nucleoside phosphonate derivative. All the nucleoside derivatives obtained were evaluated their antiviral activity including HIV.
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| Free Research Field |
医薬品化学
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