2014 Fiscal Year Final Research Report
Role of LAT1 in T cell activation
| Project/Area Number |
24590328
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
PROMSUK Jutabha 獨協医科大学, 医学部, 助教 (90541748)
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| Co-Investigator(Renkei-kenkyūsha) |
ANZAI Naohiko 獨協医科大学, 医学部, 教授 (70276054)
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| Research Collaborator |
ENDOU Hitoshi
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | LAT1 / アミノ酸トランスポーター / T細胞 / アミノ酸欠乏ストレス応答 |
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| Outline of Final Research Achievements |
We characterized L-type amino acid transporter 1 (LAT1) as an essential amino acids transporter in activated human T cells. Full activation of primary human T cells triggers the dramatic induction of LAT1. JPH203, a specific inhibitor of LAT1 suppressed amino acid incorporation and immunological function in T cells. We also identified the novel mechanism for suppression of cellular metabolism in LAT1-disturbed T cells. These results indicate that LAT1 expression is induced by full activation of T cells and LAT1 works as a central transporter for essential amino acids in activated T cells. Our result uncover the previously unknown mechanism by which T cells accelerate essential amino acid uptake upon activation and adapt to essential amino acid starvation.
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| Free Research Field |
免疫学
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