Investigation on intrinsic blood infection mechanism of Pseudomonas aeruginosa on the basis of CGH analysis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590541
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Bacteriology (including Mycology)
• Research Institution: Kagawa Prefectural College of Health Sciences
• Principal Investigator: OKUDA Jun 香川県立保健医療大学, 保健医療学部, 教授 (90334276)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 緑膿菌 / 内因性血液感染 / 上皮細胞透過メカニズム / 病原性発現メカニズム

Outline of Final Research Achievements

The type III effector exoS gene and genes encoding type IV pili were previously identified through CGH analysis. We focused on these genes, and revealed that type IV pili had ability to cause increase in Ca2+ concentration of epithelial cells through binding to Ca2+ regulator CAMLG, and it was also found that ExoS had ability to cause necrosis of human epithelial cells through binding to host factor KIF7.

Free Research Field

細菌学