Search for innate immune molecules and compounds that regulate adipose tissue inflammation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590577
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Immunology
• Research Institution: University of Toyama
• Principal Investigator: NAGAI Yoshinori 富山大学, 大学院医学薬学研究部(医学), 客員准教授 (30431761)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 免疫学 / 自然免疫 / 肥満

Outline of Final Research Achievements

We found that soluble MD-1 was produced in white adipose tissue (WAT) from high-fat diet (HFD)-fed mice. To investigate roles of soluble MD-1, we generated MD-1 transgenic (Tg) mice that produced large amount of soluble MD-1 in sera. However, no significant differences between wild-type and MD-1 Tg mice were found in body weights, adipose tissue inflammation, and insulin resistance on a HFD.
We also demonstrated that isoliquiritigenin, a component of Glycyrrhiza uralensis, suppressed the expression of RP105/MD-1 and inflammatory cytokines. In vivo analyses revealed that supplementation of isoliquiritigenin inhibited HFD-induced inflammatory responses and IL-1β production in WAT, obesity, and insulin resistance.

Free Research Field

免疫学