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2014 Fiscal Year Final Research Report

The roles of glycoprotein non-metastatic melanoma B (Gpnmb) in the modulation of ion channel activities and pain conduction

Research Project

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Project/Area Number 24590724
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pain science
Research InstitutionKanazawa University

Principal Investigator

SHIGERU Yokoyama  金沢大学, 子どものこころの発達研究センター, 特任教授 (00210633)

Co-Investigator(Kenkyū-buntansha) YOSHIKAWA Hiroaki  金沢大学, 保健管理センター, 教授 (10272981)
Project Period (FY) 2012-04-01 – 2015-03-31
Keywords痛み / 神経損傷 / Gpnmb
Outline of Final Research Achievements

The expression of glycoprotein non-metastatic melanoma B (Gpnmb) was up-regulated in both sciatic nerve and spinal cord injuries. In the lesioned sites, Gpnmb-immunoreactive cells were co-stained with markers including OX-42, ED1, and OX6. These results suggest that Gpnmb, which is produced by macrophages and microglia, may play important roles in pathophysiological processes in both peripheral and central nerve injuries.

Free Research Field

分子神経生物学

URL: 

Published: 2016-06-03  

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