Epigenetic analysis of the dementia progression in the sleep disordered breathing patients

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590882
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Osaka University
• Principal Investigator: ITO Norihisa 大阪大学, 医学(系)研究科(研究院), 助教 (00621757)
• Co-Investigator(Kenkyū-buntansha): RAKUGI Hiromi 大阪大学大学院医学系研究科, 老年・腎臓内科学, 教授 (20252679) ; OHISHI Mitsuru 鹿児島大学大学院医歯学総合研究科, 心臓血管・高血圧内科学, 教授 (50335345)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 閉塞性睡眠時無呼吸

Outline of Final Research Achievements

In this study, we designed a clinical investigation to clarify the association between the severity of obstructive sleep apnea (OSA) and cognitive function, depression, activities of daily life, muscle strength, physical performance, and cardiovascular event. We found that the muscle strength and physical performance in severe OSA group were significantly lower than mild-moderate OSA group in elderly. And we found that the left ventricular diastolic function in severe OSA group was significantly lower than mild-moderate OSA group in hypertensive patients. And we are monitoring the effect of continuous positive airway pressure and performing the epigenetic sequencing.

Free Research Field

老年病