Study on clinical isolation and identification of elderly tauopathies in elderly dementia patients

2017 Fiscal Year Final Research Report

• Project/Area Number: 24590894
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Osaka City University
• Principal Investigator: SHIMADA Hiroyuki 大阪市立大学, 大学院医学研究科, 特任教授 (90254391)
• Co-Investigator(Kenkyū-buntansha): 安宅 鈴香 大阪市立大学, 大学院医学研究科, 医員 (40549755) ; 渡辺 恭良 大阪市立大学, 大学院医学研究科, 特任教授 (40144399) ; 三木 隆己 大阪市立大学, 大学院医学研究科, 教授 (90174002)
• Project Period (FY): 2012-04-01 – 2018-03-31
• Keywords: アミロイドPET / アルツハイマー病 / 高齢者タウオパチー / アミロイド陰性認知症

Outline of Final Research Achievements

Amyloid imaging was developed as a method to visualize senile plaques in the brain, but we found that among patients diagnosed as clinically Alzheimer's disease, patients with negative PIB-PET and no evidence of accumulation of amyloid in the brain Was found to exist. We named these patient groups as PIB-negative dementia (PND), and its background pathology includes elderly tauopathies (argyrophilic grain dementia and neurofibrillary dementia) and frontotemporal dementia. In this study, PND patients who were clinically diagnosed with Alzheimer type dementia and elderly people over 80 years old who had negative amyloid imaging were extracted as subjects, and their clinical images were compared with patients with Alzheimer's disease dementia of 80 years or older (AD). As a result, neuropsychological examination showed a low value in the AD group, but no significant difference was observed in MRI and FDG-PET.There is significant differences in the CSF biomarker.

Free Research Field

Neurology