2014 Fiscal Year Final Research Report
Elucidation of the enhanced IFN action by the non-coding RNA and its application on HCV treatment
| Project/Area Number |
24590956
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OTSUKA Motoyuki 東京大学, 医学部附属病院消化器内科, 助教 (90518945)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | IFN / 非コードRNA / HCV |
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| Outline of Final Research Achievements |
miR122 was identified as an enhancer of IFN action. miR122 enhanced methylation of the SOCS3 DNA promoter and decreased its expression, which enhances IFN signaling. Apigenin decreases miR122 expression. Therefore, cotreatment of IFN and apigenin may be useful for the inhibition of HCV replication through the augmentation of IFN signaling.
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| Free Research Field |
消化器内科学
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