2014 Fiscal Year Final Research Report
ESTABLISHMENT OF A NEW FUNDAMENTAL THERAPY FOR OBSTRUCTIVE SLEEP APNEA DURING WAKEFULLNESS: UTILITY OF AN EASY, NON-INVASIVE TRAINING OF ORBICULARIS ORIS MUSCLE.
| Project/Area Number |
24591059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ANDO Shin-ichi 九州大学, 大学病院, 特任教授 (90575284)
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| Research Collaborator |
AKIHIRO Yoshiaki 日本大学, 松戸歯学部, 歯科医師
HASHIMOTO Sonomi 九州大学, 大学病院, 研究補助員
NAGAO Mitsunobu 九州大学, 大学病院, 特任准教授
CHISHAKI Akiko 九州大学, 医学研究院, 教授
SAWATARI Hiroyuki 九州大学, 大学院
RAHMAWATI Anita 九州大学, 大学院
ADACHI Kazuo 九州大学, 大学病院, 助教
ICHIKI Toshihiro 九州大学, 大学病院, 特任教授
IDE Tomomi 九州大学, 大学病院, 講師
YANAI Aika 九州大学, 大学病院, 生理検査技師
YOSHIMOTO Maiko 九州大学, 大学病院, 生理検査技師
MATSU-URA Youko 九州大学, 大学病院, 生理検査技師
KAWAHARA Gorou 九州大学, 大学病院, 生理検査技師
TADA Chie 九州大学, 大学病院, 生理検査技師
HORIKAWA Shiori 九州大学, 大学病院, 生理検査技師
SATOH Tasuku 九州大学, 大学病院, 生理検査技師
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 睡眠時無呼吸 / 血管内皮機能 / 治療学 / 心不全 / メタボリック症候群 / 高血圧 |
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| Outline of Final Research Achievements |
Current study have shown beneficial effects of the 3 months’ training of orbicularis oris to treat mild-to-moderate obstructive sleep apnea. The training significantly improved the severity of sleep apnea by decreasing in ODI, decreased the subjective daytime sleepiness and improved the endothelial function indexed by flow mediated vasodilatation. Furthermore, it improved dyslipidemia, hyperuricemia, and left ventricular systolic function, though they do not reach statistical significance.
Similar evaluations were repeated in selected subjects who agreed to have a follow-up 3months after completion or termination of the protocol, to determine if the beneficial effects continue. The temporary results indicate that the continuation would provide better results on ODI and FMD, and that the beneficial effects continues partly, even in 3-months, but worse than continuous training group. In total, 35% of the enrolled dropped out, which suggests the continuation is not much easier than CPAP.
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| Free Research Field |
医歯薬学
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