2014 Fiscal Year Final Research Report
Elucidation of the pathogenesis of acute coronary syndrome and its early diagnosis by useful biomarkers
| Project/Area Number |
24591064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEISHI Yasuchika 福島県立医科大学, 医学部, 教授 (40272067)
KUNII Hiroyuki 福島県立医科大学, 医学部, 助教 (20443856)
SAKAMOTO Nobuo 福島県立医科大学, 医学部, 助教 (80448638)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 急性冠症候群 / 早期診断 / バイオマーカー / 不安定プラーク |
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| Outline of Final Research Achievements |
As novel and useful biomarkers that may help in early diagnosis of acute coronary syndrome, neopterin, lectin-like oxidized LDL receptor-1 (LOX-1), tenascin C, CO hemoglobin, acrolein, RAGE (receptor for AGE: advanced glycation end products), and HMGB-1 (high mobility group box 1) were investigated.
The blood concentration of each substance, it was compared in acute coronary syndrome (acute myocardial infarction and unstable angina) and stable angina patients. Among them, blood levels of LOX-1 and tenascin C are significantly elevated in acute coronary syndrome patients, suggesting that they can help in early diagnosis of acute coronary syndrome.
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| Free Research Field |
循環器内科学
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