2014 Fiscal Year Final Research Report
Next-generation therapeutic angiogenesis by a pharmaceutical pretreatment for the ischemic tissue before an intramuscular injection of endothelial progenitor cells
| Project/Area Number |
24591080
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 血管新生療法 / 虚血下肢組織 / 酸化ストレス / 血管内皮前駆細胞 / アポトーシス |
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| Outline of Final Research Achievements |
Ischemic limb tissue was highly exposed to oxidative stress and a lot of endothelial progenitor cells injected to the tissue were led to apoptosis before playing the role for augmenting neovascularization in mice. The tissue condition impaired the mitochondria function, the neovascularization-related inflammatory cytokine secretory function, and the glucose transport function of the skeletal muscle cell. A pretreatment with the nebulization of propionate, which is a pharmacologic chemical agent with a potential for curing low oxygen-induced mitochondria dysfunction, for the mouse ischemic limb tissue augmented the recovery of blood flow in the limb that was subsequently injected endothelial progenitor cells. This result might be due to a recovery of the impaired functions of the skeletal muscle cell, suggesting a hint for the development of next-generation therapeutic angiogenesis.
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| Free Research Field |
循環器内科、カテーテル治療、血管新生療法
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