抗加齢に着目した難治性心不全に対する新しい治療法の開発

2014 Fiscal Year Annual Research Report

• Project/Area Number: 24591100
• Research Institution: Fukushima Medical University
• Principal Investigator: 竹石 恭知 福島県立医科大学, 医学部, 教授 (40272067)
• Co-Investigator(Kenkyū-buntansha): 及川 雅啓 福島県立医科大学, 医学部, 助教 (30457775) ; 鈴木 聡 福島県立医科大学, 医学部, 助教 (60536944)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: SMP30 / ROS / NADPH

Outline of Annual Research Achievements

ＬＤＬ受容体ノックアウトマウスにアンジオテンシンⅡを持続投与したところ、高い確率で大動脈瘤が形成された。ＳＭＰ３０ノックアウトマウスでは、アンジオテンシンⅡによる大動脈瘤の形成は認めなかった。大動脈瘤の形成におけるＳＭＰ３０の機能を検討するため、２種のノックアウトマウスを掛け合わせ、ダブルノックアウトマウスを作成した。マウスの backcross に予想よりも時間を要し、ダブルノックアウトマウスでの検討を開始した段階である。
ＳＭＰ３０ノックアウトマウスの大腿動脈を結紮し、下肢の血流をレーザードプラ血流計で観察した。血流回復は野生型マウスに比し、ＳＭＰ３０ノックアウトマウスで低下していた。下肢骨格筋の毛細血管の発達が低下しており、ＶＥＧＦの発現も低下していた。一方、ＮＡＤＰＨオキシダーゼの活性は上昇しており、酸化ストレスの増大に伴い、虚血後の側副血行路の発達が抑制されていた。このデータから、心筋梗塞後の側副血行路の形成と心機能の低下、その後の虚血性心不全の発症にＳＭＰ３０が重要な役割を演じている可能性が示唆された。

Research Products

• [Journal Article] Diacylglycerol kinase α exacerbates cardiac injury after ischemia/reperfusion (2014)
  • Author(s): Sasaki T, Shishido T, Kadowaki S, Kitahara T, Suzuki S, Katoh S, Funayama A, Netsu S, Watanabe T, Goto K, Takeishi Y, Kubota I
  • Journal Title: Heart and Vessels Volume: 29 Pages: 110-118
  • DOI: 10.1007/s00380-013-0366-6
  • Peer Reviewed
• [Journal Article] Efficacy of intrathoracic impedance and remote monitoring in patients with an implantable device after the 2011 Great East Japan Earthquake (2014)
  • Author(s): Suzuki H, Yamada S, Kamiyama Y, Takeishi Y
  • Journal Title: International Heart Journal Volume: 55 Pages: 53-57
  • DOI: 10.1536/ihj.13-21553-57
  • Peer Reviewed / Open Access
• [Journal Article] Midkine exacerbates pressure overload-induced cardiac remodeling (2014)
  • Author(s): Netsu S, Shishido T, Kitahara T, Honda Y, Funayama A, Narumi T, Kadowaki S, Takahashi H, Miyamoto T, Arimoto T, Nishiyama S, Watanabe T, Woo C, Takeishi Y, Kubota I
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 443 Pages: 205-210
  • DOI: 10.1016/j.bbrc.2013.11.083
  • Peer Reviewed / Open Access
• [Journal Article] Development of takotsubo cardiomyopathy with severe pulmonary edema before a cesarean section (2014)
  • Author(s): Suzuki T, Nemoto C, Ikegami Y, Yokokawa T, Tsukada Y, Abe Y, Shimada J, Takeishi Y, Tase C
  • Journal Title: Journal of Anesthesia Volume: 28 Pages: 121-124
  • DOI: 10.1007/s00540-013-1677-6
  • Peer Reviewed
• [Journal Article] High-sensitivity cardiac troponin T predicts non-cardiac mortality in heart failure (2014)
  • Author(s): Nakamura Y, Yoshihisa A, Takiguchi M, Shimizu T, Yamauchi H, Iwaya S, Owada T, Miyata M, Abe S, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Circulation Journal Volume: 78 Pages: 890-895
  • DOI: 10.1253/circj.CJ-13-1372
  • Peer Reviewed / Open Access
• [Journal Article] Phosphodiesterase 3A1 protects the heart against angiotensin II-induced cardiac remodeling through regulation of transforming growth factor-β expression (2014)
  • Author(s): Iwaya S, Oikawa M, Yan C, Takeishi Y
  • Journal Title: International Heart Journal Volume: 55 Pages: 165-168
  • DOI: 10.1536/ihj.13-268
  • Peer Reviewed / Open Access
• [Journal Article] Serum tenascin-C level is associated with coronary plaque rupture in patients with acute coronary syndrome (2014)
  • Author(s): Sakamoto N, Hoshino Y, Misaka T, Mizukami H, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Heart and Vessels Volume: 29 Pages: 165-170
  • DOI: 10.1007/s00380-013-0341-2
  • Peer Reviewed
• [Journal Article] Successful revascularization to right coronary artery by percutaneous coronary intervention after endovascular therapy for leriche syndrome (2014)
  • Author(s): Niizeki T, Kaneko K, Sugawara S, Sasaki T, Tsunoda Y, Takeishi Y, Kubota I
  • Journal Title: Clinical Medicine Insights: Case Reports Volume: 7 Pages: 33-36
  • DOI: 10.4137/CCRep.S13551
  • Peer Reviewed / Open Access
• [Journal Article] A case of acute myocardial infarction during perioperative period of non-cardiac surgery in a patient with antiphospholipid syndrome and a history of coronary artery bypass surgery (2014)
  • Author(s): Yokokawa T, Sugimoto K, Iwaya S, Suzuki S, Sakamoto N, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Journal of Cardiology Cases Volume: 9 Pages: 189–191
  • DOI: 10.1016/j.jccase.2014.01.008
  • Peer Reviewed
• [Journal Article] Significance of soluble lectin-like oxidized LDL receptor-1 levels in systemic and coronary circulation in acute coronary syndrome (2014)
  • Author(s): Misaka T, Suzuki S, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Saitoh S, Sawamura T, Ishibashi T, Takeishi Y
  • Journal Title: BioMed Research International Volume: 2014 Pages: 649185
  • DOI: 10.1155/2014/649185
  • Peer Reviewed / Open Access
• [Journal Article] The ascending aorta pseudoaneurysm with myocardium rupture complicated with prosthetic valve infective endocarditis after aortic valve replacement (2014)
  • Author(s): Kobayashi A, Nakazato K, Jin Y, Yamauchi H, Kaneshiro T, Oikawa M, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Journal of General Practice Volume: 2 Pages: 1000155
  • DOI: 10.4172/2329-9126.1000155
  • Peer Reviewed / Open Access
• [Journal Article] The prognositic significance of serial renal function measurements in chronic heart failure (2014)
  • Author(s): Sato T, Yamauchi H, Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Saitoh S, Takeishi Y
  • Journal Title: Journal of General Practice Volume: 2 Pages: 1000156
  • DOI: 10.4172/2329-9126.1000156
  • Peer Reviewed / Open Access
• [Journal Article] Impact of the Great East Japan Earthquake on acute myocardial infarction in Fukushima prefecture (2014)
  • Author(s): Yamaki T, Nakazato K, Kijima M, Maruyama Y, Takeishi Y
  • Journal Title: Disaster Medicine and Public Health Preparedness Volume: 8 Pages: 212-219
  • DOI: 10.1017/dmp.2014.37
  • Peer Reviewed
• [Journal Article] Impact of sleep-disordered breathing on heart rate turbulence in heart failure patients (2014)
  • Author(s): Yoshihisa A, Suzuki S, Takiguchi M, Shimizu T, Abe S, Sato T, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: PLoS One Volume: 9 Pages: e101307
  • DOI: 10.1371/journal.pone.0101307
  • Peer Reviewed / Open Access
• [Journal Article] Liver dysfunction assessed by model for end-stage liver disease excluding INR (MELD-XI) scoring system predicts adverse prognosis in heart failure (2014)
  • Author(s): Abe S, Yoshihisa A, Takiguchi M, Shimizu T, Nakamura Y, Yamauchi H, Iwaya S, Owada T, Miyata M, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: PLoS One Volume: 9 Pages: e100618
  • DOI: 10.1371/journal.pone.0100618
  • Peer Reviewed / Open Access
• [Journal Article] Pivotal roles of regulating the proline-rich tyrosine kinase 2 (PYK2) signaling in cardiac function and remodeling (2014)
  • Author(s): Takeishi Y
  • Journal Title: Journal of Molecular and Cellular Cardiology Volume: 74 Pages: 295-296
  • DOI: 10.1016/j.yjmcc.2014.06.005
  • Peer Reviewed
• [Journal Article] Predictive impact of the decreasing rate of intrathoracic impedance in worsening chronic heart failure (2014)
  • Author(s): Yamada S, Suzuki H, Kamiyama Y, Saitoh S, Takeishi Y
  • Journal Title: Journal of Interventional Cardiac Electrophysiology Volume: 40 Pages: 87-91
  • DOI: 10.1007/s10840-014-9881-3
  • Peer Reviewed
• [Journal Article] Tuberculous endocarditis complicated with acute respiratory distress syndrome: a case report (2014)
  • Author(s): Nakamura Y, Kunii H, Yoshihisa A, Sato A, Kamioka M, Nakazato K, Suzuki H, Saitoh S, Hisa S, Takeishi Y
  • Journal Title: Journal of General Practice Volume: 2 Pages: 1000160
  • DOI: 10.4172/2329-9126.1000160
  • Peer Reviewed / Open Access
• [Journal Article] Adaptive servo-ventilation therapy improves prognosis in heart failure patients with anemia and sleep-disordered breathing (2014)
  • Author(s): Suzuki S, Yoshihisa A, Miyata M, Sato T, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: International Heart Journal Volume: 55 Pages: 342-349
  • DOI: 10.1536/ihj.13-354
  • Peer Reviewed / Open Access
• [Journal Article] Suppressive effects of adaptive servo-ventilation on ventricular premature complexes with attenuation of sympathetic nervous activity in heart failure patients with sleep-disordered breathing (2014)
  • Author(s): Iwaya S, Yoshihisa A, Nodera M, Owada T, Yamada S, Sato T, Suzuki S, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Heart and Vessels Volume: 470-477 Pages: 470-477
  • DOI: 10.1007/s00380-013-0394-2
  • Peer Reviewed
• [Journal Article] A case of massive pericardial effusion associated with hypocalcemic cardiomyopathy (2014)
  • Author(s): Yokokawa T, Sakamoto K, Mizuno H, Shimizu Y, Matsui Y, Kaneko H, Ujiie Y, Miura E, Seino Y, Kijima M, Maruyama Y, Takeishi Y
  • Journal Title: Journal of Cardiology Cases Volume: 58-61 Pages: 58-61
  • DOI: 10.1016/j.jccase.2014.05.003
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac overexpression of constitutively active Gαq causes angiotensin II type1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice (2014)
  • Author(s): Matsushita N, Kashihara T, Shimojo H, Suzuki S, Nakada T, Takeishi Y, Mende U, Taira E, Yamada M, Sanbe A, Hirose M
  • Journal Title: PLoS One Volume: 9 Pages: e106354
  • DOI: 10.1371/journal.pone.0106354
  • Peer Reviewed / Open Access
• [Journal Article] Membrane type 1-matrix metalloproteinase/Akt signaling axis modulates TNF-α-induced procoagulant activity and apoptosis in endothelial cells (2014)
  • Author(s): Ohkawara H, Ishibashi T, Sugimoto K, Ikeda K, Ogawa K, Takeishi Y
  • Journal Title: PLoS One Volume: 9 Pages: e105697
  • DOI: 10.1371/journal.pone.0105697
  • Peer Reviewed / Open Access
• [Journal Article] Successful endovascular treatment of chronic total occlusion of superficial femoral artery using retrograde approach from deep femoral artery (2014)
  • Author(s): Nakamura Y, Komatsu N, Masuda A, Kunii H, Takeda H, Takeishi Y
  • Journal Title: Fukushima Journal of Medical Science Volume: 60 Pages: 43-46
  • DOI: 10.5387/fms.2013-19
  • Peer Reviewed / Open Access
• [Journal Article] Cardiovascular function and prognosis of patients with heart failure coexistent with chronic obstructive pulmonary disease (2014)
  • Author(s): Yoshihisa A, Takiguchi M, Shimizu T, Nakamura Y, Yamauchi H, Iwaya S, Owada T, Abe S, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Journal of Cardiology Volume: 64 Pages: 256-264
  • DOI: 10.1016/j.jjcc.2014.02.003
  • Peer Reviewed
• [Journal Article] Lone aspiration thrombectomy without stenting for a patient with ST-segment elevation myocardial infarction associated with coronary ectasia (2014)
  • Author(s): Yokokawa T, Ujiie Y, Kaneko H, Seino Y, Kijima M, Takeishi Y
  • Journal Title: Cardiovascular Intervention and Therapeutics Volume: 29 Pages: 339-343
  • DOI: 10.1007/s12928-013-0235-3
  • Peer Reviewed
• [Journal Article] Prognostic value of fractional flow reserve (FFR): linking physiologic severity to clinical outcomes (2014)
  • Author(s): Johnson NP, Tóth GG, Lai D, Zhu H, Açar G, Agostoni P, Appelman Y, Takeishi Y, et al
  • Journal Title: Journal of the American College of Cardiology Volume: 64 Pages: 1641-1654
  • DOI: 10.1016/j.jacc.2014.07.973
  • Peer Reviewed / Open Access
• [Journal Article] Acute coronary syndrome secondary to in-stent plaque rupture occurred at 9 years after deployment of bare metal stent (2014)
  • Author(s): Kunii H, Yokokawa T, Sato A, Kamioka M, Yoshihisa A, Yamaki T, Nagazawa G, Nakazato K, Takeishi Y
  • Journal Title: Journal of Cardiology Cases Volume: 10 Pages: 171-175
  • DOI: 10.1016/j.jccase.2014.06.013
  • Peer Reviewed
• [Journal Article] Biomarkers in heart failure (2014)
  • Author(s): Takeishi Y
  • Journal Title: International Heart Journal Volume: 55 Pages: 474-481
  • DOI: 10.1536/ihj.14-267
  • Peer Reviewed / Open Access
• [Journal Article] Long-term effects and prognosis in acute heart failure treated with tolvaptan: The AVCMA trial (2014)
  • Author(s): Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Abe Y, Saito T, Ohwada T, Suzuki H, Saitoh S, Kubota I, Takeishi Y
  • Journal Title: BioMed Research International Volume: 2014 Pages: e704289
  • DOI: 10.1155/2014/704289
  • Peer Reviewed / Open Access
• [Journal Article] Sudden cardiac arrest associated with anomalous aortic origin of the left coronary artery from the opposite sinus of Valsalva (2014)
  • Author(s): Shimizu T, Iwaya S, Suzuki S, Sakamoto N, Sugimoto K, Nakazato K, Suzuki H, Tomomi N, Yukihiro T, Saitoh S, Takeishi Y
  • Journal Title: Internal Medicine Volume: 53 Pages: 2601-2604
  • DOI: 10.2169/internalmedicine.53.2676
  • Peer Reviewed / Open Access
• [Journal Article] Impact of body mass index on mortality in heart failure patients (2014)
  • Author(s): Takiguchi M, Yoshihisa A, Miura S, Shimizu T, Nakamura Y, Yamauchi H, Iwaya S, Owada T, Miyata M, Abe S, Sato T, Suzuki S, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: European Journal of Clinical Investigation Volume: 44 Pages: 1197-1205
  • DOI: 10.1111/eci.12354
  • Peer Reviewed
• [Journal Article] Prognostic value of T-wave alternans in survivors of ventricular fibrillation or hemodynamically unstable ventricular tachycardia (2014)
  • Author(s): Yamada S, Suzuki H, Kaneshiro T, Kamiyama Y, Saitoh S, Takeishi Y
  • Journal Title: Journal of Arrhythmia Volume: 30 Pages: 485-490
  • DOI: 10.1016/j.joa.2014.02.010
  • Peer Reviewed / Open Access
• [Journal Article] Receptor for advanced glycation end products - membrane type1 matrix metalloproteinase axis regulates tissue factor expression via RhoA and Rac1 activation in high-mobility group box-1 stimulated endothelial cells (2014)
  • Author(s): Sugimoto K, Ohkawara H, Nakamura Y, Takuwa Y, Ishibashi T, Takeishi Y
  • Journal Title: PLoS One Volume: 9 Pages: e114429
  • DOI: 10.1371/journal.pone.0114429
  • Peer Reviewed / Open Access
• [Presentation] Deficiency of senescence marker protein-30 impairs collateral growth under ischemia with increasing oxidant stress (2014)
  • Author(s): Yamauchi H, Saitoh S, Owada T, Takeishi Y
  • Organizer: The 31st Annual Meeting of the International Society for Heart Research (ISHR) Japanese Section
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2014-12-28 – 2014-12-29
• [Presentation] The mitochondria-targeted antioxidant improves age-related cardiac damage (2014)
  • Author(s): Owada T, Yamauchi H, Saitoh S, Machii H, Takeishi Y
  • Organizer: The 31st Annual Meeting of the International Society for Heart Research (ISHR) Japanese Section
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2014-12-28 – 2014-12-29
• [Presentation] High mobility group box 1 promotes angiogenesis from bone marrow-derived endothelial progenitor cells after myocardial infarction (2014)
  • Author(s): Nakamura Y, Suzuki S, Shimizu T, Saitoh S, Takeishi Y
  • Organizer: The 31st Annual Meeting of the International Society for Heart Research (ISHR) Japanese Section
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2014-12-28 – 2014-12-29
• [Presentation] Phoshodiesterase 3A1 protects the heart against isoproterenol-induced cardiac injury via anti-oxidative mechanism (2014)
  • Author(s): Oikawa M, Iwaya S, Saitoh S, Takeishi Y
  • Organizer: The 31st Annual Meeting of the International Society for Heart Research (ISHR) Japanese Section
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2014-12-28 – 2014-12-29
• [Presentation] High mobility group box 1 promotes angiogenesis from bone marrow-derived endothelial progenitor cells after myocardial infarction (2014)
  • Author(s): Nakamura Y, Suzuki S, Shimizu T, Miyata M, Shishido T, Ikeda K, Saitoh S, Kubota I, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Impact of serum calcium levels on mortality of patients with heart failure and chronic kidney disease (2014)
  • Author(s): Miura S, Yoshihisa A, Nodera M, Sato A, Takiguchi M, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Impact of peripheral artery disease on prognosis in heart failure patients (2014)
  • Author(s): Nakamura Y, Yoshihisa A, Kunii H, Takiguchi M, Shimizu T, Yamauchi H, Owada T, Abe S, Suzuki S, Sugimoto K, Yamaki T, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Impact of chronic obstructive pulmonary disease on cardiovascular function and prognosis in heart failure patients (2014)
  • Author(s): Shimizu T, Yoshihisa A, Takiguchi M, Nodera M, Miura S, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Deficiency of senescence marker protein-30 impairs collateral growth by supressing nitric oxide bioactivity under ischemia (2014)
  • Author(s): Yamauchi H, Saitoh S, Owada T, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Resolution of mitochondrial oxidant stress improves aged-cardiac performance (2014)
  • Author(s): Owada T, Yamauchi H, Saitoh S, Machii H, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Presence of dissociated pulmonary vein activity after isolation depends on fibrillatory excitation in pulmonary vein (2014)
  • Author(s): Kaneshiro T, Suzuki H, Matsumoto Y, Nodera M, Kamiyama Y, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] The usefulness of combined assessment of E/e’ ratio and transmitral flow pattern to interpret cardiac condition (2014)
  • Author(s): Oikawa M, Kobayashi A, Yamauchi H, Suzuki S, Yoshihisa A, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Non-invasive positive airway pressure improves mortality in heart failure patients with preserved left ventricular ejection fraction and sleep-disordered breathing (2014)
  • Author(s): Suzuki S, Yoshihisa A, Miura S, Takiguchi M, Shimizu T, Abe S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Senescence marker protein 30 protect the cardiac injury from after ischemia reperfusion (2014)
  • Author(s): Kadowaki S, Shishido T, Narumi T, Honda Y, Nishiyama S, Takahashi H, Arimoto T, Miyamoto T, Watanabe T, Takeishi Y, Kubota I
  • Organizer: Scientific Sessions of American Heart Association 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Autonomic dysfunction exacerbates new-onset heart failure in patients with hypertension after the 2011 Great East Japan Earthquake (2014)
  • Author(s): Yamada S, Suzuki H, Misaka T, Mizukami H, Sugimoto K, Saitoh S, Suzuki F, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] The impact of plasma levels of receptor for advanced glycation end-products and high mobility group box 1 in patients with pulmonary hypertension (2014)
  • Author(s): Suzuki S, Nakazato K, Sugimoto K, Yoshihisa A, Yamaki T, Kunii H, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Echocardiographic epicardial adipose tissue relates to coronary artery plaque and calcification: comparisons with abdominal visceral adipose tissue (2014)
  • Author(s): Oikawa M, Owada T, Yamauchi H, Yoshihisa A, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Intravascular ultrasound predictors of side branch occlusion in coronary bifurcation lesions after single stent crossover technique (2014)
  • Author(s): Sakamoto N, Yamaki T, Kunii H, Nakazato K, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2014
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Vasopressin V2 receptor antagonist tolvaptan is effective in heart failure patients with reduced left ventricular systolic function and low blood pressure (2014)
  • Author(s): Suzuki S, Yoshihisa A, Abe Y, Saitoh T, Ohwada T, Suzuki H, Saitoh S, Kubota I, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2014
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Association of seismic intensity after the Great East Japan Earthquake and sudden out-of-hospital cardiac arrest (2014)
  • Author(s): Nishimura K, Takegami M, Miyamoto Y, Shimokawa H, Nakamura M, Takeishi Y, Hirata K, Shishido T, Yasuda S, Naito H
  • Organizer: Congress of the European Society of Cardiology 2014
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Cardiovascular function and prognosis of patients with heart failure coexistent with chronic obstructive pulmonary disease (2014)
  • Author(s): Nakamura Y, Yoshihisa A, Shimizu T, Owada T, Yamauchi H, Miyata M, Abe S, Suzuki S, Saitoh S, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2014
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Endogenous carbon monoxide protects against cardiac injury by collateral circulation development with acute myocardial infarction (2014)
  • Author(s): Kobayashi A, Mizukami H, Sakamoto N, Yamaki T, Kunii H, Nakazato K, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2014
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Cyclic variation of heart rate score by Holter ECG for screening sleep disordered breathing in heart failure patients (2014)
  • Author(s): Shimizu T, Yoshihisa A, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2014
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Initial results of balloon pulmonary angioplasty for patients with chronic thromboembolic pulmonary hypertension (2014)
  • Author(s): Nakazato K, Sugimoto K, Sakamoto N, Yamaki T, Kunii H, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2014
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Influence of sleep disordered breathing on heart rate turbulence in heart failure patients (2014)
  • Author(s): Shimizu T, Yoshihisa A, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2014
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] High-sensitivity cardiac troponin T predicts non-cardiac mortality in heart failure (2014)
  • Author(s): Nakamura Y, Yoshihisa A, Shimizu T, Yamauchi H, Miyata M, Suzuki S, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2014
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Impact of balloon pulmonary angioplasty for inoperable patients with chronic thromboembolic pulmonary hypertension (2014)
  • Author(s): Nakazato K, Sugimoto K, Shimizu T, Owada T, Sakamoto N, Yamaki T, Kunii H, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Euro PCR 2014
  • Place of Presentation: Paris, France
  • Year and Date: 2014-05-20 – 2014-05-23
• [Book] AGING AND HEART FAILURE. MECHANISMS AND MANAGEMENT. (2014)
  • Author(s): Takeishi Y
  • Total Pages: 475
  • Publisher: Springer, Inc.