Analysis of anti-fibrotic effects of lipid-responsible transcription factors and a search for new therapeutic agents -with special attention to hypoxic insults-

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591193
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: University of Fukui
• Principal Investigator: KIMURA Hideki 福井大学, 医学部附属病院, 准教授 (20283187)
• Co-Investigator(Kenkyū-buntansha): IWANO Masayuki 福井大学, 医学部, 教授 (20275324) ; KASUNO Kenji 福井大学, 医学部, 准教授 (60455243) ; SUGAYA Takeshi 聖マリアンナ医科大学, 医学部, 客員教授 (40381561)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ペルオキシゾーム増殖因子活性化受容体 / 脂肪酸結合蛋白 / 近位尿細管上皮細胞 / メサンギウム細胞 / サイトカイン / アンジオテンシンⅡ受容体拮抗薬 / ドキソルビシン

Outline of Final Research Achievements

Proximal tubular epithelial cells (PT)and mesangial cells (MC) are closely associated with renal fibrosis. Mouse proximal tubular epithelial cells (mProx) overexpressing human liver-type fatty acid-binding protein (L-FABP) were shown to have greater tolerance to inflammatory and hypoxic insults than mProx itself. In human cultured PT and MC, telmisartan (ARB) executed PPAR-delta functions and reduced inflammatory and pro-fibrotic effects induced by some cytokines.
Cardiac fibrosis of PPAR-a KO mice was more evident than that of control mice (S129), which was enhanced by hypoxic environments, whereas renal fibrosis was scarcely observed and similar in the two mice groups. In doxorubicin-induced glomerulopathy, PPAR-a KO mice had more proteinuria and more frequent glomerulosclerosis than S129 mice.
These suggest the cell- and tissue-protective effects of lipid responsible transcription factors and its associated proteins such as PPARs and FABPs.

Free Research Field

腎臓病学、臨床検査医学、内科臨床医学