2014 Fiscal Year Final Research Report
Establishment of mesothelial transplantation therapy in peritoenal fibrosis
| Project/Area Number |
24591240
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAMADA Chieko 順天堂大学, 医学部, 准教授 (50291662)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 腹膜透析 / 細胞移植 / 組織再生 / 中皮細胞 / 腹膜線維化 |
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| Outline of Final Research Achievements |
We hypothesized that intra-peritoneal injected mesothelial cells which usually played a central role in the restoration of the peritoneum tissue may accelerate peritoneal repair in chlorhexidine-induced peritoneal fibrosis rats.However, mesothelial transplantation aggravated peritoneal fibrosis and delayed the restoration of tissue.
According to the results, we analyzed serial morphological changes of peritoneum and transplanted mesothelial cells and expression of inflammatory cytokines and growth factors in peritoneum. Transplanted mesothelial cells transformed to fibroblastic cells stimulated by inflammatory cytokines and various growth factors in injured peritoneal tissue through activation of RAS/MAPK system. And then they secreted by oneself more inflammatory cytokines and fibrosis promoting factors and aggravated peritoneal fibrosis.
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| Free Research Field |
透析療法
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