The elucidation of the signalings of cytoskeletal reorganization involved in the development of HTLV-I-associated myelopathy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591267
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Nagasaki University
• Principal Investigator: NAKAMURA Tatsufumi 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (00198219)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Hideki 長崎大学, 病院(医学系), 講師 (10437832)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: HTLV-I関連脊髄症 / HTLV-I / 細胞内骨格再構成 / 細胞内シグナル伝達

Outline of Final Research Achievements

We investigated the factors involved in the development of HTLV-I-associated
Myelopathy(HAM)from the point of view of cytoskeletal reorganization using the efficiency of intercellular transmission of HTLV-I by co-cultivation with HTLV-I-infected T cell lines and H9/K30 luc reporter cells as an indicator. From our data, it was suggested as bellows: 1) activation of cytoskeletal reorganization by down-regulated intracellular cAMP level in HTLV-I-infected cells in HAM patients. 2) activation of CXCR4 signaling leading to Rap1 activation with activation of cytoskeleton reorganization involved in the heightened transmigrating activity to the tissues in HTLV-I-infected cells in HAM patients.

Free Research Field

神経病態免疫学