2014 Fiscal Year Final Research Report
Analysis of clonal hierarchy and microenvironment of the tumor developed in the mouse mantle cell lymphoma model
| Project/Area Number |
24591391
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kyoto University |
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Principal Investigator |
NISHIKORI Momoko 京都大学, 医学(系)研究科(研究院), 助教 (60378635)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 悪性リンパ腫 / マウスモデル |
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| Outline of Final Research Achievements |
Malignant lymphoma is classified into many histologic subtypes. They exhibit their own biological features that are shaped during their differentiation and maturation steps of lymphocytes in vivo. In this study, we have generated mouse lymphoma models that are triggered by CCND1 and BCL2 overexpression, and compared phenotypic and genotypic features of these tumors. We have found several important biological mechanisms on lymphoma histology determination that are considered common to humans.
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| Free Research Field |
血液腫瘍学
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